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Cover image of Geriatric Bioscience
Cover image of Geriatric Bioscience
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Geriatric Bioscience

The Link between Aging and Disease

David Hamerman, M.D.
foreword by Robert N. Butler, M.D.

Publication Date
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It is increasingly important for physicians who treat older persons, and for researchers on aging, to understand how molecular biology informs clinical expressions of aging and age-related conditions such as osteoporosis, diabetes, osteoarthritis, frailty, cancer, and dementia. Dr. David Hamerman translates basic scientific concepts into precepts of clinical practice and sheds light on the links among biology, natural aging, longevity, and disease.

Exploring the connections between disease and the science behind it, Geriatric Bioscience addresses how mechanisms of inflammation, cytokine...

It is increasingly important for physicians who treat older persons, and for researchers on aging, to understand how molecular biology informs clinical expressions of aging and age-related conditions such as osteoporosis, diabetes, osteoarthritis, frailty, cancer, and dementia. Dr. David Hamerman translates basic scientific concepts into precepts of clinical practice and sheds light on the links among biology, natural aging, longevity, and disease.

Exploring the connections between disease and the science behind it, Geriatric Bioscience addresses how mechanisms of inflammation, cytokine expression, and stress responses influence disease and how preventive gerontology in the practice of medicine could compress morbidity. Hamerman also discusses cutting-edge therapies such as cyclo-oxygenases, bisphosphonates, statins, cytokine inhibitors, and hormone therapies.

Examining the science of geriatrics and converting its concepts into clinical applications, this groundbreaking work provides clinicians and researchers with a solid foundation for a greater understanding of the diagnosis, treatment, and prevention of age-related diseases as well as recommendations for promoting healthy aging.

Reviews

Reviews

Hamerman leads the advanced and careful reader to a better understanding of the relationships between the biology of aging and the emergence of aging-related diseases.

A unique presentation based on the author's many decades of research and experience in the science of aging. It is extremely well documented with more than a thousand references and a helpful reference... an important source of information from an expert.

The nexus between obesity, heart disease, diabetes, cancer, and Alzheimer's disease is tantalizing. It takes the hand of a master to synthesize so much material and give a unified overarching view of the relationship between aging and disease. This skillful hand is seen in the smooth flow of the book and a most pleasurable style of writing.

A must-read for clinicians providing primary care in geriatrics

An inspiring, concise, comprehensive, and stimulating primer of the field for aspiring gerontologists, geriatricians, and other physicians who will care for elderly persons.

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About

Book Details

Publication Date
Status
Available
Trim Size
6
x
9
Pages
316
ISBN
9780801886928
Illustration Description
8 color illus., 4 halftones, 14 line drawings
Table of Contents

Foreword by Robert N. Butler
Preface
1. The Emergence and Future of Geriatrics
2. An Introduction to Concepts of Molecular Biology
3. Aging
I. Trends in the Aging of the Population
II. What Is Aging? Can We

Foreword by Robert N. Butler
Preface
1. The Emergence and Future of Geriatrics
2. An Introduction to Concepts of Molecular Biology
3. Aging
I. Trends in the Aging of the Population
II. What Is Aging? Can We Distinguish betweenAging and Disease?
III. Mechanisms of Aging
IV. Longevity: Genetics of Extended Life Span or Risk for Adverse Events
4. Interrelations of Certain Aging-related Conditions
I. Cytokines, Inflammation, and Responses to Stress
II. Atherosclerosis: Risk Factors for Cardiovascular Disease
III. The Metabolic Syndrome and Type 2 Diabetes
IV. Osteoporosis
V. Osteoarthritis
VI. Frailty and Related Conditions: Anorexia, Sarcopenia, Exercise
VII. Cancer
VIII. Alzheimer Disease
5. Interactive Therapies Significant for an Aging Population
I. Cyclooxygenases
II. Statins
III. Bisphosphonates
IV. Thiazolidinediones and Peroxisome Proliferatoractivated Receptor
V. Cytokine Inhibitors as a Landmark for Newer Anti-inflammatory Therapies
VI. Hormonal Therapies
6. Preventive Gerontology
I. The Compression or Expansion of Morbidity?
II. Healthy Lifestyle Practices
III. "Successful Aging"
Epilogue
Glossary
References
Index

Author Bios
Featured Contributor

David Hamerman, M.D.

David Hamerman, M.D., is Distinguished University Professor of Medicine at the Albert Einstein College of Medicine, founder of the Division of Geriatrics at Montefiore Medical Center, and editor of Osteoarthritis: Public Health Implications for an Aging Population, also published by Johns Hopkins.
Featured Contributor

Robert N. Butler, M.D.

Robert N. Butler, M.D., is president and chief executive officer of the International Longevity Center–USA and professor of geriatrics at the Brookdale Department of Geriatrics and Adult Development at the Mount Sinai Medical Center in New York City. From 1975 to 1982 he was the founding director of the National Institute on Aging of the National Institutes of Health. In 1982 he founded the first...